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Hereditary Bleeding Disorders

Understanding Hereditary Bleeding Disorders

Coagulation disorders, also called clotting disorders, are a group of diseases where the blood does not clot properly. As a result, patients with coagulation disorders bleed for a long time after injuries, during menstruation, or with surgery. Depending on the severity of the disease, there may often be spontaneous bleeding into the joints, muscles or other parts of the body. A tendency to bleed comes from defects in the blood components such as coagulation proteins and platelets. The body produces 13 different coagulation proteins, which are also known as coagulation factors or clotting factors.If one or more of these factors is missing or not working properly, a coagulation disorder may result. Coagulation disorders are relatively rare and some of them, such as haemophilia, may be either congenital (hereditary) or acquired. Congenital coagulation disorders are caused by genetic defects and are already present at birth. Treatment in each case depends on the disease and its severity. With proper investigation and treatment, patients with coagulation disorders can lead a full life.

  • Over 300,000

    people have bleeding disorders

  • 30%

    of people with hemophilia have no family history of it

  • 1 in 100 *

    people are born with von Willebrand Disease

* Unless otherwise indicated, all statistics are global.

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von Willebrand Disease

Von Willebrand Disease (VWD) is a bleeding disorder caused by a deficiency of a protein called von Willebrand Factor.

Hemophilia A

Hemophilia A is a bleeding disorder caused by a deficiency in blood clotting Factor VIII.

Hemophilia B

Hemophilia B is a bleeding disorder caused by a deficiency in blood clotting Factor IX.

Factor XIII Deficiency

Congenital factor XIII deficiency is a bleeding disorder characterized by unstable blood clots.

Fibrinogen Deficiency

Congenital fibrinogen deficiency describes a range of conditions characterized by absent, insufficient or dysfunctional fibrinogen.